Table 2.
Disease-associated gene analysis of the 72 potential M6a’s interactors.
| ID | Annotation | p-value | FDR B&H | FDR B&Y | Bonferroni | Genes from input (72) | Protein symbol | |
|---|---|---|---|---|---|---|---|---|
| Disease | C0004352 | Autistic Disorder | 1.84E-10 | 3.041E-07 | 2.43E-06 | 3.041E-07 | 20 (27%) | Gja1, Dpysl2, Stx1a, Nrxn3, Stxbp1, Thy1, Scamp5, Tnc, Pclo, Scn2a, Cntnap1, Syn1, Syn2, Snap25, App, Aqp4, Plp1, Slc1a2, Atp2b2, Slc1a3 |
| C0014544 | Epilepsy | 1.05E-09 | 8.625E-07 | 6.89E-06 | 1.73E-06 | 19 (26%) | Gja1, Dpysl3, Stx1a, Stxbp1, Sv2a, Scn2a, Syn1, Slc17a7, Syn2, Grin1, Atp1a2, Atp1a3, App, Grm1, Aqp4, Slc1a2, Slc1a3, Vdac1, Slc12a5 | |
| C0036341 | Schizophrenia | 2.40E-09 | 1.32E-06 | 1.05E-05 | 3.96E-06 | 28 (38%) | Nptn, Dpysl2, Stx1a, Nrxn3, Stxbp1, Sv2a, Pclo, Scn2a, Ncan, Lrp1, Syn1, Slc17a7, Syn2, Syp, Bcan, Grin1, Snap25, App, Grm1, Ppia, Aqp4, Eno2, Plp1, Slc1a2, Slc1a3, Cnp, Mog, Slc12a5 | |
| C0002395 | Alzheimer’s Disease | 2.10E-05 | 6.93E-03 | 0.055 | 0.035 | 26 (34%) | Gja1, Dpysl2, Dpysl3, Thy1, Synj1, Sv2a, Anxa5, Lrp1, Syn1, Slc17a7, Syn2, Syp, Syt1, Bcan, Grin1, Snap25, App, Ppia, Aqp4, Eno2, Slc1a2, Slc1a3, Cnp, Mog, Hsp90, Vdac1 | |
| C0086237 | Epilepsy, Cryptogenic | 5.30E-06 | 2.19E-03 | 0.017 | 0.009 | 7 (9, 7%) | Gja1, Scn2a, Grm1, Slc1a2, Slc1a3, Vdac1, Slc12a5 | |
| C0005586 | Bipolar Disorder | 2.61E-05 | 7.18E-03 | 0.057 | 0.043 | 16 (22%) | Vapa, Dpysl2, Synj1, Pclo, Ncan, Slc17a7, Syn2, Syp, Grin1, Snap25, Atp1a1, Atp1a2, Atp1a3, App, Slc1a2, Slc1a3 | |
| C0036572 | Seizures | 4.81E-05 | 0.010 | 0.081 | 0.079 | 14 (19%) | Gja1, Stxbp1, Synj1, Sv2a, Scn2a, Slc17a7, Syn2, Grin1, Atp1a2, App, Aqp4, Slc1a2, Slc1a3, Slc12a5 | |
| C0011570 | Mental Depression | 4.92E-05 | 0.010 | 0.081 | 0.081 | 14 (19%) | Gja1, Dpysl2, Pclo, Syn1, Syp, Grin1, Snap25, Atp1a3, App, Grm1, Aqp4, Slc1a2, Cnp, Hsp90 | |
| C1269683 | Major Depressive Disorder | 1.27E-04 | 2.11E-02 | 1.70E-01 | 2.19E-01 | 13 (19%) | Gja1, Pclo, Ncan, Lrp1, Slc17a7, Snap25, App, Plp1, Slc1a2, Slc1a3, Cnp, Mog, Hsp90 | |
| C0011581 | Depressive disorder | 1.28E-04 | 0.022 | 0.176 | 0.211 | 14 (19%) | Gja1, Dpysl2, Pclo, Syn1, Syp, Grin1, Snap25, Atp1a3, App, Grm1, Aqp4, Slc1a2, Cnp, Hsp90 |
The table shows the overlap of the associated genes in the top 10 diseases. The analysis was done with the ToppFun application of the ToppGene Suit using data sourced from DisGeNET.