TABLE 3.

Univariate and Multivariate Cox Regression Analysis of Overall Survival in each patient set.

Variables	Univariable Model			Multivariable Model
	HR	95% CI of HR	p-value	HR	95% CI of HR	p-value
Discovery set (n = 120)
Risk group
High vs. Low	2.815	1.741–4.552	<0.001	3.089	1.900–5.023	<0.001
Age	1.036	1.008–1.066	0.012	1.045	1.015–1.075	0.003
Stage
II vs. I	2.088	0.495–8.801	0.316
III vs. I	3.122	0.756–12.895	0.116
Gender
Male vs. Female	0.582	0.324–1.046	0.070
Alcohol
Yes vs. No	0.790	0.496–1.258	0.321
Internal testing set (n = 57)
Risk group
High vs. Low	2.254	0.963–5.275	0.061
Age	1.009	0.97–1.05	0.656
Stage
II vs. I	Inf	0 – Inf	0.998
III vs. I	Inf	0 – Inf	0.998
Gender
Male vs. Female	1.214	0.523–2.821	0.651
Alcohol
Yes vs. No	0.981	0.48–2.004	0.958
TCGA testing set (n = 160)
Risk group
High vs. Low	1.858	1.073–3.217	0.027	1.998	1.054–3.786	0.034
Age	0.991	0.971–1.012	0.394
Stage
II vs. I	2.020	0.589–6.931	0.264	1.772	0.516 – 3.786	0.364
III vs. I	5.078	1.447–17.820	0.011	4.614	1.314 – 16.203	0.017
IV vs. I	14.918	3.734–59.601	< 0.001	11.837	2.936 – 47.712	< 0.001
Gender
Male vs. Female	2.081	0.833–5.198	0.116
Alcohol
Yes vs. No	0.718	0.428–1.205	0.210