TABLE 1.
Antimicrobial activity of rScyreprocin, rSCY2, and rScyreprocin/rSCY2.
| Microorganisms | CGMCC No.a | rScyreprocin | rSCY2 | rScyreprocin/rSCY2 | |
| MIC (μM)b | MBC (μM)b | MIC (μM) | MIC (μM) | ||
| Gram-negative bacteria | |||||
| Pseudomonas fluorescens | 1.0032 | <0.5 | 1–2 | >50 | 1.5–3 |
| Pseudomonas stutzeri | 1.1803 | 0.5–1 | 1–2 | >50 | 1.5–3 |
| Shigella flexneri | 1.1868 | <0.5 | >15 | >50 | 1.5–3 |
| Escherichia coli | 1.2389 | 2–4 | >15 | >50 | 3–6 |
| Escherichia coli MC1061 | – | 2–4 | 4-8 | >50 | 3–6 |
| Aeromonas hydrophila | 1.2017 | >15 | >15 | >50 | >24 |
| Vibrio fluvialis | 1.1609 | 1–2 | 2–4 | >50 | 6–12 |
| Vibrio harveyi | 1.1593 | 2–4 | 8–16 | >50 | 6–12 |
| Vibrio alginolyticus | 1.1833 | 4–8 | 16–32 | >50 | 6–12 |
| Vibrio parahaemolyticus | 1.1615 | 8–16 | >32 | >50 | >24 |
| Gram-positive bacteria | |||||
| Micrococcus luteus | 1.634 | <0.5 | <0.5 | 25–50 | <1.5 |
| Micrococcus lysoleikticus | 1.0634 | <0.5 | 1–2 | 12.5–25 | 3–6 |
| Staphylococcus aureus | 1.363 | <0.5 | 2–4 | >50 | <1.5 |
| Corynebacterium glutamicum | 1.1886 | 2–4 | 2–4 | 25–50 | 3–6 |
| Bacillus subtilis | 1.108 | 1–2 | 4–8 | 12.5–25 | 3–6 |
| Fungi | |||||
| Cryptococcus neoformans | 2.1563 | 1–2 | 8–16 | >50 | 8–16 |
| Candida albicans | 2.2411 | 2–4 | 16–32 | >50 | 6–12 |
| Candida krusei | 2.1857 | 8–16 | >32 | >50 | 16–32 |
| Candida parapsilosis | 2.1846 | 16–32 | >32 | >50 | >24 |
| Candida tropicalis | 2.1975 | 16–32 | >32 | >50 | >24 |
| Pichia pastoris | 2.2238 | 4–8 | >30 | >50 | 16–32 |
| Fusarium graminearum | 3.349 | 8–16 | >32 | >50 | 16–32 |
| Fusarium solani | 3.584 | 8–16 | >32 | >50 | 16–32 |
| Fusarium oxysporum | 3.6785 | 16–32 | >32 | >50 | 16–32 |
| Aspergillus niger | 3.0316 | 4–8 | >32 | >50 | 32–64 |
| Aspergillus ochraceus | 3.583 | 4–8 | >32 | >50 | 8–16 |
| Aspergillus fumigatus | 3.5835 | 4–8 | >32 | >50 | 16–32 |
| Neurospora crassa | 3.1604 | 16–32 | >32 | >50 | 16–32 |
aChina general microbiological culture collection number; bMIC and MBC were presented as an interval [A]–[B]: [A] was the highest concentration tested with visible microbial growth, whereas [B] was determined as the lowest concentration without visible microbial growth (n = 3).