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. 2020 Jul 24;10:1198. doi: 10.3389/fonc.2020.01198

Figure 6.

Figure 6

Immune contexture CD4/IFNGR2/CD68/CSF1R exerts synergistic effects and predicts prognostic neoadjuvant chemotherapy responses. (A) Correlation analyses of the mRNA expression levels of tumor-infiltrating immune cells with gene signatures CD4, CD68, IFNGR2, and CSF1R from the real-time quantitative PCR of OSA primary tumors (n = 45). (B) Comparison showing the mRNA expression levels of tumor-infiltrating immune cells with CD4/IFNGR2/CD68/CSF1R predicting prognostic neoadjuvant chemotherapy responses in OSA target lesions (n = 45); t-test was used to assess significance. (C) Immunohistochemistry for CD4/CD68/IFNGR2/CSF1R expression in the PR or PD tissues in paraffin tissue sections of osteosarcoma patients who underwent neoadjuvant chemotherapy. (D) Comparison of the density per HPF of CD4+/CD68+ cells and immunohistochemistry score of IFNGR2/CSF1R in non-responders (PD) and responders (PR and SD). PD, progressive disease; PR, partial response; SD, stable disease.