Table 1.
Proteins are significantly different from the summary background during head-down bed rest without countermeasures (HDBR) and with resistive vibration exercises (HDBR+RVE).
| Gene names | Protein names | HDBR | HDBR+RVE | ||||
|---|---|---|---|---|---|---|---|
| p-value | Welch's t-test difference | p-value | Welch's t-test difference | ||||
| IGKC | Ig kappa chain C region | 1.41E-03 | −3.0 | ↓ | |||
| AMBP | Alpha-1-microglobulin | 2.56E-04 | −1.4 | ↓ | 1.62E-08 | 2.1 | ↑ |
| F2 | Prothrombin | 1.48E-05 | −1.3 | ↓ | |||
| AFM | Afamin | 1.15E-05 | −0.9 | ↓ | |||
| C6 | Complement component C6 | 8.05E-04 | −0.7 | ↓ | |||
| GPX3 | Glutathione peroxidase 3 | 8.41E-03 | −0.6 | ↓ | |||
| CFI | Complement factor I | 7.42E-03 | −0.6 | ↓ | |||
| BCHE | Cholinesterase | 3.87E-03 | −0.5 | ↓ | |||
| AGT | Angiotensinogen | 3.47E-03 | −0.5 | ↓ | |||
| CP | Ceruloplasmin | 2.53E-05 | −0.5 | ↓ | |||
| SERPINC1 | Antithrombin-III | 4.62E-05 | −0.5 | ↓ | |||
| PCYOX1 | Prenylcysteine oxidase 1 | 3.98E-03 | −0.4 | ↓ | |||
| MCAM | Cell surface glycoprotein MUC18 | 1.95E-03 | −0.2 | ↓ | |||
| SERPINF2 | Alpha-2-antiplasmin | 2.32E-03 | 0.4 | ↑ | |||
| APOE | Apolipoprotein E | 2.42E-03 | 0.4 | ↑ | |||
| CPN1 | Carboxypeptidase N catalytic chain | 1.98E-03 | 0.4 | ↑ | |||
| C4A | Complement C4-A | 1.36E-03 | 0.4 | ↑ | |||
| C5 | Complement C5 | 1.41E-03 | 0.4 | ↑ | |||
| ITIH4 | Inter-alpha-trypsin inhibitor heavy chain H4 | 1.96E-03 | 0.5 | ↑ | |||
| ITIH2 | Inter-alpha-trypsin inhibitor heavy chain H2 | 2.51E-04 | 0.5 | ↑ | |||
| PROS1 | Vitamin K-dependent protein S | 2.37E-03 | 0.5 | ↑ | |||
| SERPIND1 | Heparin cofactor 2 | 3.78E-04 | 0.5 | ↑ | 3.19E-03 | −0.4 | ↓ |
| SERPINA4 | Kallistatin | 1.26E-03 | 0.6 | ↑ | |||
| HP | Haptoglobin | 4.67E-03 | 0.7 | ↑ | |||
| C1QB | Complement C1q subcomponent subunit B | 2.36E-06 | 0.7 | ↑ | |||
| IGHG1 | Ig gamma-1 chain C region | 4.65E-03 | 0.7 | ↑ | |||
| FGA | Fibrinogen alpha chain | 2.54E-03 | 0.7 | ↑ | 4.38E-03 | 0.7 | ↑ |
| FGG | Fibrinogen gamma chain | 4.68E-05 | 0.7 | ↑ | |||
| FGB | Fibrinogen beta chain | 2.07E-06 | 0.8 | ↑ | |||
| C1QC | Complement C1q subcomponent subunit C | 5.59E-08 | 0.8 | ↑ | |||
| APOM | Apolipoprotein M | 1.05E-05 | 0.9 | ↑ | |||
| AZGP1 | Zinc-alpha-2-glycoprotein | 5.35E-04 | 0.9 | ↑ | |||
| IGHG2 | Ig gamma-2 chain C region | 2.24E-03 | 1.6 | ↑ | |||
| APOA1 | Apolipoprotein A-I | 4.03E-05 | −0.6 | ↓ | |||
| MST1 | Hepatocyte growth factor-like protein | 4.96E-03 | 0.5 | ↑ | |||
| ECM1 | Extracellular matrix protein 1 | 2.73E-04 | 0.5 | ↑ | |||
| C1S | Complement C1s subcomponent | 1.86E-04 | 0.5 | ↑ | |||
| ITIH3 | Inter-alpha-trypsin inhibitor heavy chain H3 | 1.27E-03 | 0.5 | ↑ | |||
| KLKB1 | Plasma kallikrein | 6.88E-03 | 0.5 | ↑ | |||
| CFB | Complement factor B | 3.58E-05 | 0.6 | ↑ | |||
| GPLD1 | Phosphatidylinositol-glycan-specific phospholipase D | 1.11E-03 | 0.6 | ↑ | |||
| ATRN | Attractin | 2.19E-04 | 0.6 | ↑ | |||
| PLG | Plasminogen | 9.26E-03 | 0.9 | ↑ | |||
| GC | Vitamin D-binding protein | 7.73E-03 | 1.2 | ↑ | |||