Table 1.
Differential expression of genes of the TGFβ signaling pathway.
| Gene | Fold regulationCoCl2 2h vs CTR(p value) | Fold regulationCoCl2 8h vs CTR(p value) | Fold regulationCoCl28h vs 2h(p value) | Regulating miRNAs (tarbase) |
|---|---|---|---|---|
| TGFB1 | 1.9466 (p<0.01) | 2.7128 (p<0.05) | 1.3936 | miR-27a |
| TGFBR1 | −1.419 (p<0.05) | 1.3352 | 1.7166 (p<0.05) | miR-20a, miR-27a, miR-27b, miR-20b, (microT-CDS), miR-381 (microT-CDS) |
| TGFBR2 | 2.327 (p<0.05) | 2.7213 (p<0.05) | 1.1694 | miR-20a, miR-20b |
| SMAD2 | 1.5014 | 1.8547 (p<0.05) | 1.2354 | miR-20b, miR-206 (microT-CDS), miR-381 (microT-CDS) |
The microRNAs (miRNAs), targeting each gene, were predicted with application of Tarbase, or whenever written with microT-CDS algorithm.