Table 5.

Mechanical strength in cortical bone in female miR21^Δot mice.

	miR21f/f	miR21Δot	% change
Yield Force (N)	8.978 ± 0.602	8.66 ± 0.486	−3.53
Ultimate Force (N)	11.662 ± 1.013	11.628 ± 1.168	−0.29
Pre-Yield Displacement (μm)	215.073 ± 22.801	221.153 ± 23.920	2.83
Post-yield Displacement (μm)	981.928 ± 380.192	1328.576 ± 292.795*	35.30
Total Displacement (μm)	1197.002 ± 376.015	1549.729 ± 285.952*	29.47
Stiffness (N/mm)	47.874 ± 6.39	45.632 ± 4.105	−4.68
Pre-yield Work (mJ)	1.049 ± 0.171	1.019 ± 0.1349	−2.82
Post-yield Work (mJ)	8.200 ± 1.991	9.791 ± 1.303*	19.40
Total Work (mJ)	9.249 ± 1.910	10.811 ± 1.298*	16.88
Yield Stress (MPa)	36.905 ± 4.038	35.253 ± 4.983	−4.48
Ultimate Stress (MPa)	47.798 ± 4.570	47.076 ± 5.806	−1.51
Pre-yield Strain (με)	19432.98 ± 1646.98	19533.12 ± 2215.71	0.52
Total Strain (με)	108546.8 ± 34714.9	137001.5 ± 27440.5*	26.21
Modulus (GPa)	2.156 ± 0.195	2.094 ± 0.239	−2.89
Resilience (MPa)	0.391 ± 0.077	0.368 ± 0.080	−5.74
Toughness (MPa)	3.449 ± 0.818	3.875 ± 0.660	12.33

^*p<0.05 versus miR-21^f/f mice, by t-test (n=10-12)