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. 2020 Mar 20;33(3):153–160. doi: 10.1293/tox.2020-0007

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©2020 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.

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Fig. 3. — Characteristics of representative epithelial and non-epithelial patient-derived xenograft (PDX) models established with the NOD.Cg-Prkdc^scid Il2rg^tm1Sug/Jic mouse (NOG mouse). A: Tumors of epithelial cell origin. 3rd generation tissues from a case of lung squamous cell carcinoma with characteristic cancer pearls, and renal clear cell carcinoma with sarcomatous features. B: Tumors of non-epithelial cell origin. 3rd generation tissues from a case of embryonic rhabdomyosarcoma with poorly adhering, round-shaped cells and occasional racquet shaped or myofibroblast-like features, and gastrointestinal stromal tumor (GIST) with an interlacing growth pattern of spindle cells.