Fig. 7.
Proposal of a method for early detection and early termination of lymphoproliferative lesions (LPL) cases at necropsy. A: Splenomegaly is observed in LPL-NOD.Cg-Prkdcscid Il2rgtm1Sug/Jic mice (NOG mice). B: The following decisions can be made at necropsy by gross examination of the mouse spleen: If there is no splenomegaly in the 1st and 2nd generations, passage should proceed, but if there is splenomegaly in the 2nd generation regardless of the results of the 1st generation, further passage should be terminated. If there is splenomegaly in the 1st generation but not in the 2nd generation, the tissue should be passaged, and the 2nd generation spleen should be examined histopathologically.