Figure 2.

Association between TMB and patient demographics and molecular patterns. (A) The variations in the TMB status were correlated with the differences in age in the whole cohort, with statistically significant differences (Wilcoxon test); (B) high TMB was associated with old age in lung cancer patients (Wilcoxon test). Male patients were more prone to having high TMB than females in both the whole cohort (C) and lung cancer subgroups (D) (Wilcoxon test); (E) microsatellite instability-high commonly indicated high TMB (Wilcoxon test); (F) DDR deficiency and (G) HRR deficiency were both correlated with high TMB (Wilcoxon test). TMB, tumor mutation burden; DDR, DNA damage response.