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. 2020 Jul;8(14):866. doi: 10.21037/atm-20-654

Figure 2.

Figure 2

Establishment of TF-based regulatory network. (A) Heat map of differentially expressed TFs; the blue to red spectrum indicates low to high TF expression. (B) Volcano plot of TFs; the blue dots represent downregulated TFs, the red dots represent upregulated TFs and the black dots represent TFs that were not significantly differentially expressed. (C) Regulatory network of TFs and prognostic IRGs; the green nodes represent prognostic IRGs with hazard ratios <1 (P<0.05), the red nodes represent prognostic IRGs with hazard ratios >1 (P<0.05), the blue nodes represent TFs that correlated with the PDEIRGs in terms of their mRNA levels (correlation coefficient >0.4 and P<0.001), the black lines indicate negative regulatory relationships and the red lines indicate positive regulatory relationships. TF, transcription factor; IRGs, immune-related genes.