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. 2020 Jul;8(14):886. doi: 10.21037/atm-20-5006

Figure 5.

Figure 5

Inhibition of HOTAIR suppressed medulloblastoma tumor growth in a xenograft model. (A) Tumor sizes were measured; (B) measurement of the mean tumor weight; (C) the expressions of HOTAIR, miR-483-3p, and CDK4 were evaluated by RT-PCR; (D) immunohistochemical staining analysis was conducted and observed under 40× scope to detect Ki67 and PCNA, TUNEL assay was used to analyze cell apoptosis; (E,F,G) the statistical analysis of Ki67 positive cells, PCNA positive cells and apoptotic cells were shown by the bar graphs; (H) the regulation of proliferation and apoptosis in medulloblastoma with HITAIR/miR-483-3p/CDK4. *, P<0.01 compared with the control group. HOTAIR, HOX transcript antisense RNA; ⊣, inhibition; →, increase for upward and decrease for downward arrows; CDK4, cyclin-dependent kinase 4; PCNA, proliferating cell nuclear antigen.