Fusidic acid (yellow) has been modeled into its predicted binding site in mtEFG1 by superimposing a
T. thermophilus model (pdb: 4V5F Gao
et al,
2009). Critical residues for FA function are indicated. T121 and G127 correspond to T84 and F87 in
T. thermophilus. The ordered conformation of switch 1 likely prevents binding of FA to mtEFG1. The bacterial structure, in which FA binding only occurs when switch 1 is disordered, is shown for comparison on the right (pdb:4V5F (Gao
et al,
2009).