Figure EV6. Cross‐kingdom structural analysis of the OTU fold.

• A
  Cartoon representation of the CE clan, human adenovirus 2 proteinase crystal structure (PDB 1AVP) colored in a rainbow gradient from N‐ to C‐terminus. The catalytic triad residues are marked on both the structure and the linear color gradient above, showing their positions with respect to each other and the overall sequence.
• B
  Structural alignment of the core protease folds (central β‐sheet and two supporting α‐helices) from human adenovirus proteinase 2 of the CE clan (light blue, PDB 1AVP) and EschOTU (orange). Surrounding regions are less well conserved and shown as semi‐transparent.