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Mediation effect of WMH loads in the relationship between diastolic orthostatic hypotension (mm hg) and future cognitive decline. Path C shows the total effect of diastolic orthostatic hypotension associated with future cognitive decline as measured by the MoCA slope, and path C′ shows the same path after taking the WMH load into account as a mediator. Asterisks indicate significant paths (P < 0.05). MoCA, Montreal Cognitive Assessment Score; WMH, white matter hyperintensity.
