FIG. 2.

Mediation effect of WMH loads in the relationship between total SCOPA‐AUT score and future cognitive decline. Path C shows the total effect of SCOPA‐AUT associated with future cognitive decline as measured by the MoCA slope, and path C′ shows the same path after taking the WMH load into account as a mediator. Asterisks indicate significant paths (P < 0.05). MoCA, Montreal Cognitive Assessment Score; SCOPA‐AUT, Scales for Outcomes in Parkinson's Disease–Autonomic; WMH, white matter hyperintensity.