TABLE 4.
Linear regression analysis assessing the relationship between the slope of changes in MoCA score after baseline visit and baseline WMH and SCOPA‐AUT scores, controlling for age, sex, and segmentation sequence
| Cohort | ||||
|---|---|---|---|---|
| HC | PD | |||
| Measure | Estimate | P‐Value | Estimate | P‐Value |
| Intercept | 0.046 | 0.764 | 0.027 | 0.812 |
| Age | −0.239 | 0.014 | −0.211 | 0.0006 |
| Sex | 0.314 | 0.060 | −0.186 | 0.114 |
| Modality | −0.248 | 0.128 | 0.003 | 0.976 |
| WMH load | −0.006 | 0.947 | −0.146 | 0.019 |
| SCOPA | 0.094 | 0.221 | −0.124 | 0.026 |
Model: MoCA slope ∼ WMH load + SCOPA + Age + Sex + Sequence + Cardiovascular Medications. Significant associations are displayed in bold.
MoCA, Montreal Cognitive Assessment; WMH, white matter hyperintensity; SCOPA‐AUT, Scales for Outcomes in Parkinson's Disease–Autonomic; HC, healthy control; PD, Parkinson's disease.