Table 5.
Comparisons of clinical outcomes according to the value of CPIS and appropriateness of antimicrobial therapy
| CPIS value | Derivation cohort | Validation cohort | |||||
|---|---|---|---|---|---|---|---|
| Appropriate antimicrobial therapy (n = 431) | Inappropriate antimicrobial therapy (n = 258) | P value | Appropriate antimicrobial therapy (n = 95) | Inappropriate antimicrobial therapy (n = 111) | P value | ||
| Days on mechanical ventilation | < 7 | 14 (8–26) | 13 (8–24) | 0.59 | 17.5 (11–32.5) | 19 (12–28) | 0.82 |
| ≥ 7 | 14 (8–26) | 18 (12–29.5) | 0.03 | 16 (11–33) | 17 (11–26.5) | 0.72 | |
| Days in the ICU | < 7 | 21 (13–31) | 21.5 (14–36) | 0.37 | 24 (14.5–36) | 25 (14–36.5) | 0.76 |
| ≥ 7 | 19 (13–32) | 25 (15–40.5) | 0.052 | 20 (13–30) | 20 (15–41) | 0.77 | |
| ICU mortality | < 7 | 88 (33%) | 65 (34%) | 0.93 | 19 (30%) | 23 (32%) | 0.82 |
| ≥ 7 | 62 (38%) | 24 (28%) | 0.12 | 7 (23%) | 15 (39%) | 0.13 | |
Data are presented as number (%) or median (interquartile range)
ICU Intensive care unit; CPIS Clinical pulmonary infection score
p values < 0.05 are indicated in italic characters