Fig. 1.

Schematic overview of analysis pipeline. (Top row) The preprocessed diffusion data were used to generate tractography results. The tractography results were affinely coregistered to the brain-extracted preoperative structural scan. The postoperative scan was rigidly coregistered to add the lead localization. (Bottom row) 3D-rendering of one patient’s structural scan, overlaid with the reconstructed anterior thalamic radiation (ATR), superolateral medial forebrain bundle (slMFB), and deep brain stimulation (DBS) leads. Views are as follows: (left) sagittal (right hemisphere), (middle) side-view (from the left), and (right) axial view (top-down). Low visualization thresholds (1–2% of the maximum in the vALIC) for the tracts were chosen here to display the full extent of the forward connectivity.