Table 4.

Metabolic activities correlation analysis of individual HLMs (n = 9) toward NBIF, phenacetin, paclitaxel, β-estradiol and propofol.

Enzyme	Probe substrate	Metabolite	r value	p value
CYP1A2	phenacetin-N-deacetylation	NBIF-oxidation (M2)	0.525	0.147
CYP1A2	phenacetin-N-deacetylation	NBIF-oxidation (M3)	0.860	0.003, **
CYP1A2	phenacetin-N-deacetylation	NBIF-oxidation (M4)	0.775	0.014, *
CYP1A2	phenacetin-N-deacetylation	NBIF-oxidation (M5)	0.382	0.310
CYP2C8	paclitaxel-6-hydroxylation	NBIF-oxidation (M2)	0.675	0.046, *
CYP2C8	paclitaxel-6-hydroxylation	NBIF-oxidation (M3)	0.829	0.006, **
CYP2C8	paclitaxel-6-hydroxylation	NBIF-oxidation (M4)	0.577	0.104
CYP2C8	paclitaxel-6-hydroxylation	NBIF-oxidation (M5)	0.284	0.460
UGT1A1	β-estradiol-3-O-glucuronidation	NBIF-O-glucuronidation (G1)	0.822	0.007, **
UGT1A1	β-estradiol-3-O-glucuronidation	NBIF-O-glucuronidation (G2)	0.689	0.040, *
UGT1A9	propofol-O-glucuronidation	NBIF-O-glucuronidation (G1)	0.768	0.016, *
UGT1A9	propofol-O-glucuronidation	NBIF-O-glucuronidation (G2)	0.860	0.003, **

Note: NBIF, neobavaisoflavone. All experiments were performed in triplicate.

^*p < 0.05

^**p < 0.01

^***p < 0.001.