TABLE 3.

Changes in Anticholinergic Medication Use

	RCT Participants n = 46	Local External Control n = 146	National External Control n = 1,745
ADS change, mean (95% CI)a	−0.33 (−0.72, 0.07)b	−0.20 (−0.42, 0.02)	−0.33 (−0.39, −0.26)
Decreased, n (%)
ADS	16 (34.8)	40 (27.4)	508 (29.2)
Number of anticholinergics	13 (28.3)	37 (25.3)	486 (27.9)
Number of strong anticholinergics	4 (8.7)	14 (9.6)	171 (9.8)

^aAdjusted for baseline number of medications and anticholinergic burden.

^bNot statistically significantly different from local or national samples; P = 0.58 and 0.28, respectively.

ADS = Anticholinergic Drug Scale; CI = confidence interval; RCT = randomized controlled trial