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. 2020 Jul 21;11(7):829. doi: 10.3390/genes11070829

Figure 2.

Figure 2

BARD1 variants in non-breast and non-gynecological cancers (A) BARD1 isoforms. Full-length BARD1 (BARD1-FL) and different variants that occur due to alternative splicing. The table depicts in which cancer types the isoforms are oncogenic or tumor suppressors. * indicates multiple forms of alternative splicing. The γ isoform is either composed of only exons 1–3 or exons 1–3, 5–11. The ω1 isoform is depicted in this figure, which begins at a.a. 382. The ω2 isoform begins in exon 4 at a.a. 407 while the ω3 isoform begins in exon 7 at a.a. 538. NB: neuroblastoma. CRC: colorectal cancer. NSCLC: non-small cell lung cancer. AML: acute myeloid leukemia. (B) SNPs and genetic mutations in the BARD1 gene. BARD1 is composed of 11 exons (white) and introns (gray) and includes 5′ and 3′ UTR (black lines). Genetic variants of BARD1 in NB (red), CRC (blue), pancreatic cancer (green), nephroblastoma (pink), and Ewing sarcoma (purple) are depicted as lines localized to the region of the mutation. Only exons are drawn to scale.