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. 2020 Jul 16;11(7):810. doi: 10.3390/genes11070810

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alterations to CENP-A PTMs and/or to HJURP expression levels contribute to CIN and tumor progression. (A) Alterations to CENP-A posttranslational modifications (PTMs) can reduce recruitment of CCAN and kinetochore components, reduce CENP-A deposition at centromeres, and lead to chromosome segregation defects. (B) HJURP overexpression stabilizes CENP-A in the pre-nucleosomal complex and CENP-A protects HJURP from degradation. In p53 null cancers, upregulated HJURP levels become critical for maintaining centromere integrity and preventing apoptosis as p53-mediated DNA checkpoints are lost, leading to HJURP epigenetic addiction that contributes to tumor survival and progression.