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. 2020 Jul 16;25(14):3242. doi: 10.3390/molecules25143242

Scheme 2.

Scheme 2

Key steps of the proposed mechanism for the Fischer indolization: (a) N-arylhydrazone generation, (b) enamine formation, (c) [3,3]-sigmatropic rearrangement, (d) re-aromatization, (e) cyclization, (f) indole formation.