Table 3.

Antiproliferative activity (IC₅₀ in µM) of chalcones (2–16) and dihydropyrazoles (17–31).

Compound	DU-145	Compound	DU-145
2	432 ± 2	17	351 ± 2
3	176 ± 2	18	119 ± 2
4	393 ± 2	19	327 ± 2
5	147 ± 2	20	149 ± 2
6	141 ± 2	21	134 ± 2
7	31 ± 2	22	262 ± 2
8	254 ± 2	23	206 ± 2
9	292 ± 1	24	257 ± 2
10	138 ± 2	25	131 ± 2
11	353 ± 2	26	271 ± 2
12	256 ± 2	27	211 ± 2
13	209 ± 2	28	173 ± 2
14	206 ± 2	29	162 ± 2
15	94 ± 2	30	84 ± 2
16	17 ± 1	31	32 ± 1
Methotrexate	11 ± 1

Data are presented as mean ± SD (n = 3). All the compounds and the standard were dissolved in dimethyl sulfoxide (DMSO), diluted with culture medium containing 0.1% DMSO. The control cells were treated with culture medium containing 0.1% DMSO.