Figure 1.

Pedigrees of the four affected Shetland Sheepdogs. Squares represent males and circles represent females. Filled symbols indicate affected dogs and open symbols indicate non-affected dogs. Symbols with question marks indicate dogs of an unknown phenotype. The strike-through symbol represents a dog that died before the beginning of the investigation. According to the owner, this dog had similar clinical signs as the other affected Shetland Sheepdogs. The genotypes at the PCK2:c.1658G>A variant are given for dogs, from which samples were available (see Section 3.5).