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Initial screening results of potential tankyrase inhibitors. Dot blot reflects the amount of the poly-ADP-ribose product of the PARP enzymatic reaction. Positions A1 and B1—tankyrase in the absence of inhibitors; C1 and D1—tankyrase with a positive control inhibitor XAV939, no product; A5 and D5—PARP1 as positive control. Compounds A1–A7 are applied respectively at positions A2 and B2, C2 and D2, A3 and B3, C3 and D3, A4 and B4, C4 and D4, B5 and C5.
