Table 2.
Association analysis of the MMP1 rs1799750 -/G, MMP10 rs486055 C/T and MMP12 rs2276109 T/C polymorphisms with non-contact anterior cruciate ligament (ACL) rupture.
| Polymorphism | Model | CON (n = 202) |
% | ACLR # (n = 227/228) |
% | OR | 95% CI | p * | |
|---|---|---|---|---|---|---|---|---|---|
| MMP1 rs1799750 -/G |
Codominant | ||||||||
| -- | 55 | 27.23 | 59 | 25.99 | 1.00 | 0.922/0.924 | |||
| -G | 102 | 50.50 | 119 | 52.42 | 1.09 | 0.69 | 1.71 | ||
| GG | 45 | 22.28 | 49 | 21.59 | 1.02 | 0.59 | 1.75 | ||
| Dominant | |||||||||
| -- | 55 | 27.23 | 59 | 25.99 | 1.00 | 0.772/0.774 | |||
| -G + GG | 147 | 72.77 | 168 | 74.01 | 1.07 | 0.69 | 1.64 | ||
| Recessive | |||||||||
| -- + -G | 157 | 77.72 | 178 | 78.41 | 1.00 | 0.863/0.865 | |||
| GG | 45 | 22.28 | 49 | 21.59 | 0.96 | 0.61 | 1.52 | ||
| Overdominant | |||||||||
| -- + GG | 100 | 49.50 | 108 | 47.58 | 1.00 | 0.690/0.693 | |||
| -G | 102 | 50.50 | 119 | 52.42 | 1.08 | 0.74 | 1.58 | ||
| MMP10 rs486055 C/T | Codominant | ||||||||
| CC | 131 | 64.85 | 163 | 71.49 | 1.00 | 0.335/0.400 | |||
| CT | 63 | 31.19 | 58 | 25.44 | 0.74 | 0.48 | 1.13 | ||
| TT | 8 | 3.96 | 7 | 3.07 | 0.70 | 0.25 | 1.99 | ||
| Dominant | |||||||||
| CC | 131 | 64.85 | 163 | 71.49 | 1.00 | 0.140/0.177 | |||
| CT + TT | 71 | 35.15 | 65 | 28.51 | 0.74 | 0.49 | 1.11 | ||
| Recessive | |||||||||
| CC + CT | 194 | 96.04 | 221 | 96.93 | 1.00 | 0.616/0.773 | |||
| TT | 8 | 3.96 | 7 | 3.07 | 0.77 | 0.27 | 2.16 | ||
| Overdominant | |||||||||
| CC + TT | 139 | 68.81 | 170 | 74.56 | 1.00 | 0.186/0.201 | |||
| CT | 63 | 31.19 | 58 | 25.44 | 0.75 | 0.49 | 1.15 | ||
| MMP12 rs2276109 T/C | Codominant | ||||||||
| TT | 144 | 71.29 | 158 | 69.30 | 1.00 | 0.678/0.584 | |||
| CT | 55 | 27.23 | 64 | 28.07 | 1.06 | 0.69 | 0.69 | ||
| CC | 3 | 1.49 | 6 | 2.63 | 1.82 | 0.45 | 0.45 | ||
| Dominant | |||||||||
| TT | 144 | 71.29 | 158 | 69.30 | 1.00 | 0.652/0.807 | |||
| CT + CC | 58 | 28.71 | 70 | 30.70 | 1.10 | 0.73 | 0.73 | ||
| Recessive | |||||||||
| TT + CT | 199 | 98.51 | 222 | 97.37 | 1.00 | 0.402/0.300 | |||
| CC | 3 | 1.49 | 6 | 2.63 | 1.79 | 0.44 | 0.44 | ||
| Overdominant | |||||||||
| TT + CC | 147 | 72.77 | 164 | 71.93 | 1.00 | 0.846/0.936 | |||
| CT | 55 | 27.23 | 64 | 28.07 | 1.04 | 0.68 | 0.68 | ||
ACLR—anterior cruciate ligament rupture, CON—control; * p-values/p value adjusted for sex; OR—odds ratio, 95% CI—confidence intervals, # 227 ACLR subjects for MMP1 rs1799750 -/G, 228 ACLR subjects for MMP10 rs486055 C/T and MMP12 rs2276109 T/C.