Table 1.
Characteristics of RNAs enriched in RNA granules.
| RNA Granule | Enriched RNAs (Examples) | Depleted RNAs (Examples) | Prefer Long mRNAs? | Prefer Translationally Repressed mRNAs? |
|---|---|---|---|---|
| P-bodies | Translationally repressed mRNAs [17] | 18S and 28S rRNAs [17] | N/A | Yes |
| Stress granules | mRNAs with longer coding regions and 3′UTRs [29,37] lncRNAs [29] 18S rRNA [124] |
Membrane-associated mRNAs [29] gapdh [29] 28S rRNA [124] |
Yes | Yes |
| P granules (C. elegans) |
Long mRNAs with low ribosome occupancy [67] Germ-cell specific mRNAs [67] |
N/A | Yes | Yes |
| Polar granules (D. melanogaster) |
Germ-cell specific mRNAs [49,87,125] | oskar [49,125] | N/A | Yes, but with exceptions [58,59,87,105,108,109,110,111] |