Table 1.

The ten most significant loci shared between heifer conception rate at first Service (HCR1) and the number of times bred to achieve a pregnancy (TBRD).

BTA 1	BP Position 2	SNP ID 3	Model 4	HCR1 p-Value 5	TBRD p-Values 6	Positional Candidate Genes 7
1	94,300,486	rs41606324	additive dominant	6.28 × 10−24 3.65 × 10−24	3.97 × 10−25 2.01 × 10−25	NLGN1
4	117,606,629	rs137620917	additive dominant	1.47 × 10−20 1.47 × 10−20	4.67 × 10−59 4.67 × 10−59	DPP6
5	40,576,651	rs43434026	recessive	8.48 × 10−9	3.03 × 10−10	MUC19
9	45,148,825	rs41609220	additive	4.89 × 10−33	5.72 × 10−38	-
10	63,217,046	rs133388647	dominant	6.98 × 10−20	1.36 × 10−19	-
14	25,633,578	rs134826452	additive dominant	1.67 × 10−21 1.67 × 10−21	7.83 × 10−21 7.83 × 10−21	-
14	50,291,072	rs41913814	recessive	2.64 × 10−11	1.21 × 10−21	-
19	47,475,942	rs41917870	recessive	2.14 × 10−9	8.34 × 10−10	EFCAB3
23	23,965,902	rs41634508	additive dominant	4.77 × 10−21 4.77 × 10−21	5.55 × 10−25 5.55 × 10−25	PKHD1
27	21,375,791	rs132728892	additive dominant	1.84 × 10−35 1.84 × 10−35	2.90 × 10−32 2.90 × 10−32	-

¹ Chromosome location of the locus. ² Single nucleotide polymorphism (SNP) location as measured by numbered nucleotides (base pairs; bp) in reference to the UMD 3.1 genome assembly [24]³ The most significant SNP in the locus associated with heifer conception rate is listed. The rs number is the assigned SNP identity from the National Center for Biotechnology Information SNP database [30]. ⁴ Genome-wide association analysis model. ⁵ Significance (p-value) of the most significant SNP associated with heifer conception rate at first service (HCR1). ⁶ Significance (p-value) of the most significant SNP associated with number of times bred to achieve a pregnancy (TBRD) in heifers. ⁷ Positional candidate genes are genes located within 17.8 kb 5′ or 3′ of the associated SNP(s).