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. 2020 Jul 11;25(14):3170. doi: 10.3390/molecules25143170

Figure 3.

Figure 3

Aged mice display alternations in the expression of genes involved in cellular metabolism. mRNA expression in the hypothalamus of both young and aged C57BL/6 mice was analyzed. The mRNA levels of (A) glucose transporter-1 (Glut1) and (B) Glut3 were elevated in the hypothalamus of aged mice compared with young mice. Aged mice showed decreased levels of hypothalamic genes including (C) HK1 and (D) LDH. (E) No significant differences in hypothalamic MCT1 mRNA were observed between young and aged mice. The mRNA levels of (F) FATP, (G) PPAR-α, (H) CPT1α, (I) HMGCS1, and (J) HMGCL genes were increased in the hypothalami of the aged mice compared with young mice. Results are presented as mean ± SEM. n = 6–7 for each group. * p < 0.05, ** p < 0.01 for the aged group versus the young group.