Table 2.
The frequencies of common SNP haplotypes found among the chromosomes bearing c.516G>C, c.-23+1G>A, c.235delC in comparison with the normal chromosomes.
| Haplotypes * | Frequency of Haplotypes | x2 | p | |
|---|---|---|---|---|
| Mutant Chromosomes |
Normal Chromosomes | |||
| Haplotypes for c.516G>C: rs747931-rs5030700-rs3751385-rs2274083-rs2274084-rs1411911768-rs9552101-rs117685390-rs877098 | ||||
| T-C-C-A-G-T-G-T-C | 1 | 0.0217 | 120 | <10−26 |
| other haplotypes | 0 | 0.9783 | - | - |
| Haplotypes for c.-23+1G>A: rs747931-rs5030700-rs3751385-rs2274083-rs2274084-rs1411911768-rs9552101-rs117685390-rs877098 | ||||
| C-C-C-A-G-C-G-T-C | 0.9167 | 0.0532 | 64 | <10−10 |
| C-C-C-A-G-C-G-T-T | 0.0833 | 0.1540 | 0.047 | 0.4488 |
| other haplotypes | 0 | 0.7928 | - | - |
| Haplotypes for c.235delC: rs747931-rs5030700-rs3751385-rs2274083-rs2274084-rs1411911768-rs9552101-rs117685390-rs877098 | ||||
| T-C-C-A-G-C-G-T-T | 1 | 0.1587 | 26 | 1 |
| other haplotypes | 0 | 0.8413 | - | - |
* The most frequent haplotypes are shown in bold. The SNP alleles specific for the common SNP haplotypes are highlighted by frames.