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. 2020 Sep;1865(9):158737. doi: 10.1016/j.bbalip.2020.158737

Fig. 1.

Fig. 1

TG catabolism and proliferation of MEFs. (A, D, G) TG hydrolase activity of (A) WT/AKO MEFs, (D) WT MEFs, or (G) Control/ATGL-OE MEFs cell lysates in the absence or presence of 40 μM Atglistatin© (AI) or DMSO as vehicle control was determined using a radiolabeled TG substrate. (B, E, H) TG content of (B) WT/AKO MEF, (E) WT MEF or (H) Control/ATGL-OE MEFs in the absence or presence of 40 μM Atglistatin© or DMSO as vehicle control was determined after Folch extraction using a commercially available kit. (C, F, I) Proliferation of (C) WT/AKO MEFs, (F) WT/AKO MEFs in the absence or presence of 40 μM Atglistatin© or DMSO as vehicle control, or (I) Control/ATGL-OE MEFs was analyzed using a hemocytometer at the indicated timepoints. Data represent mean values of n = 3–6 ± sd. Significance was determined by student's t-test (*p ≤ 0.05, **p ≤ 0.01).