Fig. 5.

Effect of redox-modified CeO₂NP inhalation on Iba-1 and GFAP protein levels.

Levels of Iba-1 (B, C, D) and GFAP (E, F, G) were assessed by Western blot analysis in lysates of the cortex of female C57BL/6J (B, E), ApoE^-/- (C, F) and 5xFAD (D, G) exposed to clean air or CeO₂ NPs with different doping of Zr (representative blots are shown in A). Data were normalized to the level of β-actin and expressed in mean ± SEM. * Statistical significance different from the respective control in Dunnet post-hoc test following one-way ANOVA with p < 0.05. Number of animals per group: ApoE^-/-: control (n = 5); CeO₂ (n = 5); 27% ZrO₂-doped CeO₂ (n = 5); 78% ZrO₂-doped CeO₂ (n = 4). 5xFAD: control (n = 4); CeO₂ (n = 4); 27% ZrO₂-doped CeO₂ (n = 4); 78% ZrO₂-doped CeO₂ (n = 4). C57BL/6J: control (n = 5); CeO₂ (n = 5); 27% ZrO₂-doped CeO₂ (n = 5); 78% ZrO₂-doped CeO₂ (n = 5).