Fig. 6.

Effect of redox-modified CeO₂NP inhalation on Nrf2 and HO-1 protein levels.

Lysates of the cortex of C57BL/6J (B, E), ApoE^-/- (C, F) and 5xFAD (D, G) mice exposed to clean air or CeO₂ NPs with different doping of Zr were subjected to Western blot analysis. Levels of Nrf2 (B, C, D) and HO-1 (E, F, G) were normalized to the level of β-actin and expressed in mean ± SEM. Representative blots are shown in A. Number of animals per group: ApoE^-/-: control (n = 5); CeO₂ (n = 5); 27% ZrO₂-doped CeO₂ (n = 5); 78% ZrO₂-doped CeO₂ (n = 4). 5xFAD: control (n = 4); CeO₂ (n = 4); 27% ZrO₂-doped CeO₂ (n = 4); 78% ZrO₂-doped CeO₂ (n = 4). C57BL/6J: control (n = 5); CeO₂ (n = 5); 27% ZrO₂-doped CeO₂ (n = 5); 78% ZrO₂-doped CeO₂ (n = 5).