Table 1.
Study Cohort Characteristics by Phenotype at the End of Follow-Up
| Normal ECG and Echo (n = 158) | Abnormal ECG Only (n = 41) | HCM (n = 86) | p Value | |
|---|---|---|---|---|
| Genotype | ||||
| MYBPC3 | 76 (48.1) | 9 (22.0) | 38 (44.2) | <0.001 |
| MYH7 | 28 (17.7) | 16 (39.0) | 25 (29.1) | |
| MYL2 | 4 (2.5) | 0 (0.0) | 2 (2.3) | |
| TNNI3 | 32 (20.3) | 3 (7.3) | 4 (4.7) | |
| TNNT2 | 11 (7.0) | 12 (29.3) | 11 (12.8) | |
| TPM1 | 5 (3.2) | 1 (2.4) | 3 (3.5) | |
| ACTC1 | 0 (0.0) | 0 (0.0) | 1 (1.2) | |
| Multiple mutations | 2 (1.3) | 0 (0.0) | 2 (2.3) | |
| Age, yrs | 16.9 (7.5–32.6) | 6.9 (3.5–12.6) | 16.0 (9.2–35.0) | <0.001 |
| Male | 72 (39.3) | 24 (51.1) | 55 (61.8) | 0.002 |
| Follow-up duration, yrs | 9.1 (3.3–13.7) | 6.9 (3.5–10.5) | 7.7 (5.4–11.6) | 0.276 |
| Hypertension | 5 (3.2) | 1 (2.4) | 7 (8.1) | 0.206 |
| CMR | 75 (47.5) | 20 (48.8) | 50 (58.1) | 0.270 |
Values are n (%) or median (interquartile range). p value is for overall comparison.
CMR = cardiac magnetic resonance; ECG = electrocardiogram; HCM = hypertrophic cardiomyopathy (i.e., fulfills diagnostic criteria).