Table 3.

Univariable and Multivariable Predictors of HCM Penetrance With Cox Regression

Predictor	Univariable Analysis			Multivariable Analysis
	HR	95% CI	p Value	HR	95% CI	p Value
Age (10 yrs)	1.11	0.98–1.26	0.106	1.31	1.12–1.52	<0.001
Genotype
MYBPC3	1.00	–	–	1.00	–	–
MYH7	1.22	0.73–2.02	0.447	1.13	0.67–1.92	0.644
MYL2	0.69	0.17–2.86	0.607	0.83	0.19–3.57	0.801
TNNI3	0.22	0.08–0.62	0.004	0.19	0.07–0.55	0.002
TNNT2	0.97	0.49–1.90	0.927	0.67	0.34–1.33	0.249
TPM1	0.78	0.24–2.53	0.677	0.41	0.12–1.39	0.152
ACTC1	8.91	1.19–66.91	0.034	13.51	1.67–109.14	0.015
Multiple mutations	0.84	0.20–3.49	0.806	1.22	0.29–5.21	0.786
Male	2.03	1.32–3.14	0.001	2.91	1.82–4.65	<0.001
Abnormal ECG∗	3.11	2.03–4.76	<0.001	4.02	2.51–6.44	<0.001
CMR	1.38	0.89–2.12	0.148	Analysis stratified for CMR
Hypertension	1.90	0.87–4.14	0.107	-

CI = confidence interval; HR = hazard ratio; other abbreviations as in Table 1.

^∗At baseline or during follow-up.