REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti pS6	Cell Signaling Technology	Cat#5364S; RRID:AB_10694233
Rabbit anti Cystatin-C	Abcam	Cat#ab109508; RRID:AB_10888303
Rabbit anti collagen III	Abcam	Cat#ab7778; RRID:AB_306066
Rabbit anti TNFα	Abcam	Cat#ab6671; RRID:AB_305641
Goat anti-GFP	Abcam	Cat#ab6673; RRID:AB_305643
Mouse anti SMA	Abcam	Cat#ab7817; RRID:AB_262054
Rabbit anti-ZO1	Abcam	Cat#ab216880
Rabbit anti E-cadherin	Abcam	Cat#ab15148; RRID:AB_301693
Rabbit anti-Ki67	Thermo Scientific	Cat#MA5-14520; RRID:AB_10979488
Rabbit anti-pAKT S473	Cell Signaling Technology	Cat#4060S; RRID:AB_2315049
Rabbit anti HIF-1 alpha	Abcam	Cat#ab82832; RRID:AB_1860665
Rabbit anti Ts6	Cell Signaling Technology	Cat#2217S; RRID:AB_331355
Mouse anti HSP90	Abcam	Cat#ab13495; RRID:AB_1269122
Chemicals, Peptides, and Recombinant Proteins
Dapagliflozin (Forxiga)	AstraZeneca	N/A
Dapagliflozin	Cayman Chemical	Cat# 11574
Insulin degludec	Novo Nordisk	N/A
2-amino-2-norbornaecarboxylic acid (BCH)	Sigma-Aldrich	Cat#A7902
TRIzol	Bio-Lab	Cat# 959758027100
Periodic Acid–Schiff	Sigma-Aldrich	Cat#395B-1KT
Rapamycin	Cell Signaling	Cat#9904
Torin-1	Cell Signaling	Cat#14379
Clarity Western ECL Blotting Substrate	Bio-Rad	Cat#1705061
FastStart SYBR-Green Master	Applied Biosystems	Cat#4385610
Critical Commercial Assays
β-Hydroxybutyrate colorimetric assay	Cayman Chemical	Cat#700190
Insulin ELISA kit	Crystal Chem	Cat#90080
BCAA kit	BioVision	Cat#K564
Albumin kit	Bethyl Laboratories	Cat#E99-134
KIM-1 kit	R&D Systems	Cat#MKM100
XF cell mito stress test kit	Agilent Technologies	Cat#103015-100
cDNA synthesis kit	Applied Biosystems	Cat#4368814
Experimental Models: Cell Lines
LLC-PK1	ATCC	Cat#CL-101
HK-2	ATCC	Cat#CRL-2190
Experimental Models: Organisms/Strains
Akita	Jackson Laboratories	Cat# 003548
Sglt2Cre;Tsc1fl/fl	This paper	N/A
Sglt2Cre;Raptorfl/+	This paper	N/A
Sglt2-Cre; Rosa26-YFP	This paper	N/A
Oligonucleotides
RT-PCR primers	See STAR Methods for all the primer sequences	N/A
Software and Algorithms
ImageJ	ImageJ Software	https://imagej.nih.gov/ij/
GraphPad Prism	GraphPad Software	https://www.graphpad.com
NIS-Elements software	NIS-Elements software	Nikon instruments Inc.