Table 3.

The Pharmacokinetic Parameters

Parameters	Drugs	Free ATST/TAGE	ATST/TAGE CNPs	RGD-ATST/TAGE CNPs
Cmax (L/kg/h)	ATST	19.5±1.5	20.1±1.9	21.3±2.6
	TAGE	17.6±1.7	18.7±1.8	18.3±1.5
T1/2 (h)	ATST	1.5±0.3	5.8±0.9*	9.3±1.1*
	TAGE	1.3±0.2	7.9±0.7*	11.3±0.9*
AUC (mg/L.h)	ATST	35.9±2.8*	156.8±8.9*	307.6±19.8*
	TAGE	30.3±3.1*	128.3±6.7*	289.5±13.7*

Note: *P<0.05 compared with Free ATST/TAGE.

Abbreviations: C_max, plasma drug peak concentration; T_1/2, half-life of drugs; AUC, area under the curve.