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. Author manuscript; available in PMC: 2020 Aug 3.
Published in final edited form as: Trends Neurosci. 2019 Feb 12;42(4):263–277. doi: 10.1016/j.tins.2019.01.002

Figure 1, Key Figure: Main axes of SOX10-mediated oligodendrocyte differentiation.

Figure 1, Key Figure:

Four main SOX10 axes have been recently characterized: the CHD8-BRG1-OLIG2 axis, the Calcineurin-NFAT axis, the MYRF axis and the TCF7L2 axis. The proteins that are involved in this circuit are marked in cyan, myelin transcripts are marked in yellow, and post-translational modifications (de-phosphorylation of NFAT and ZFP24 and formation of MYRF-homotrimer) are marked in magenta.