Fig. 7.

Depletion of hsa_circ_0000517 repressed HCC growth in vivo. a Tumor volumes were measured once a week from the day of injection. b Tumor weight in the sh-hsa_circ_0000517 and sh-NC groups was assessed on day 35. c, d The expression of hsa_circ_0000517 and miR-326 in tumor tissues of the sh-hsa_circ_0000517 and sh-NC groups was detected with qRT-PCR. e Protein levels of PCNA and SMAD6 in tumor tissues of the sh-hsa_circ_0000517 and sh-NC groups were examined by western blot analysis. *P < 0.05