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. 2020 Aug 3;11:337. doi: 10.1186/s13287-020-01850-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Spleen and liver sites of extramedullary hematopoiesis. a Spleen weight at the termination of the follow-up. Increased spleen weight was associated with elevated number of megakaryocytes only in TBI IM or SC f-hPSC-treated mice, as compared to the naïve controls (b). The spleen cellularity and size, which may represent the extent of spleen damage which varied in the few surviving Veh-Cont mice, are presented (c Vs d, with magnification of selected area). Increased total number of spleen cells and the presence of HSCs (identified as Lin- negative, [cKit+, SCA1+ and CD150+) in f-hPSC-treated mice, as compared with Veh-Cont and Naïve mice, may suggest increased Spleen-EMH. Total numbers of isolated cells, HSC frequency, and their total counts in the spleen are presented in e–g (p values:*< 0.05, **< 0.01, ***< 0.001, ****< 0.0001)