Table 2.

Treatments and dosing schedule

Medication	Licensed dose range in the elderly	Notes from the registered summary of product characteristics
Vortioxetine	5–20 mg/day	The minimum effective dose of 5 mg vortioxetine once daily should always be used as an initial dose for participants aged ≥ 65 years. Caution should be exerted when prescribing to elderly participants at doses > 10 mg vortioxetine once daily
Sertraline	50–200 mg/day	Caution is required in the elderly, because these patients may be at greater risk of hyponatraemia
Paroxetine	20–40 mg/day	In the elderly, increased plasma concentrations of paroxetine have been reported, however, within the range observed in younger patients. The treatment should start at the same doses used in adults
Citalopram	10–20 mg/day	In the elderly, half of the dose range prescribed in adults is required
Escitalopram	5–10 mg/day	In the elderly, half of the dose range prescribed in adults is required
Fluoxetine	20–60 mg/day	Caution is required when the dose is increased in the elderly, and generally the daily dose should not be above 40 mg/day. The maximum recommended dose is 60 mg/day
Fluvoxamine	100–300 mg/day	In elderly participants, titration should be slower and the dosage should always be established with caution