Table 4.

Comparison of time to diagnosis in neurological vs non-neurological onset by means of ANCOVA

	Mean Time to diagnosis	Standard Error	95% CI	p value
All cohort (n = 611)
Neurological onset (n = 554)	4.5	0.197	4.2–5	0.001
Non-neurological onset (n = 57)	6.7	0.618	5.5–7.9
Typical-onset patients (n = 508)
Neurological onset (n = 454)	4.1	0.209	3.7–4.6	0.0002
Non-neurological onset (n = 56)	6.5	0.594	5.2–7.8

Comparisons were performed both 1) in the entire cohort and 2) in the typical-onset patients. Mean, Standard Error, 95% confidence intervals (CI) and p values estimated by bias-corrected and accelerated bootstrap are reported. Estimates are adjusted for age at examination, age at onset and presentation before/after 1996. Statistically significant results are reported in bold.