Table 3.

Significant level of pairwise comparison

Age Group	G1 ~ G2	G1 ~ G3	G1 ~ G4	G2 ~ G3	G2 ~ G4	G3 ~ G4
Prevalence (%)	7.29 ~ 8.82	7.29 ~ 10.53	7.29 ~ 10.55	8.82 ~ 10.53	8.82 ~ 10.55	10.53 ~ 10.55
P value (prevalence)	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.97
AUC (LR)	0.759 [0.728–0.789] ~ 0.760 [0.750–0.770]	0.759 [0.728–0.789] ~ 0.746 [0.731–0.760]	0.759 [0.728–0.789] ~ 0.725 [0.713–0.736]	0.760 [0.750–0.770] ~ 0.746 [0.731–0.760]	0.760 [0.750–0.770] ~ 0.725 [0.713–0.736]	0.746 [0.731–0.760] ~ 0.725 [0.713–0.736]
P value (LR)	0.81	0.13	< 0.001	0.022	< 0.001	0.004
AUC (SVM)	0.767 [0.743–0.790] ~ 0.766 [0.753–0.780]	0.767 [0.743–0.790] ~ 0.742 [0.729–0.756]	0.767 [0.743–0.790] ~ 0.723 [0.702–0.744]	0.766 [0.753–0.780] ~ 0.742 [0.729–0.756]	0.766 [0.753–0.780] ~ 0.723 [0.702–0.744]	0.742 [0.729–0.756] ~ 0.723 [0.702–0.744]
P value (SVM)	0.10	0.005	< 0.001	0.12	< 0.001	0.06
AUC (LB)	0.750 [0.728–0.773] ~ 0.753 [0.733–0.772]	0.750 [0.728–0.773] ~ 0.738 [0.727–0.750]	0.750 [0.728–0.773] ~ 0.712 [0.701–0.724]	0.753 [0.733–0.772] ~ 0.738 [0.727–0.750]	0.753 [0.733–0.772] ~ 0.712 [0.701–0.724]	0.738 [0.727–0.750] ~ 0.712 [0.701–0.724]
P value (LB)	0.73	0.33	0.002	0.09	< 0.001	0.009
AUC (RF)	0.784 [0.769–0.800] ~ 0.766 [0.754–0.777]	0.784 [0.769–0.800] ~ 0.754 [0.741–0.768]	0.784 [0.769–0.800] ~ 0.723 [0.709–0.737]	0.766 [0.754–0.777] ~ 0.754 [0.741–0.768]	0.766 [0.754–0.777] ~ 0.723 [0.709–0.737]	0.754 [0.741–0.768] ~ 0.723 [0.709–0.737]
P value (RF)	0.11	0.006	< 0.001	0.11	< 0.001	0.004

Abbreviation:AUC the area under the receiver operating characteristic curve for top-200 features with under-sampling, LR Logistic Regression, SVM Support Vector Machine, LB LogistBoost, RF Random Forest, G1 18–35 age group; G2 36–55 age group, G3 56–65 age group, G4 > 65 age group. P value in bold represents p < 0.05