Table 4.

Evidence synthesis on the content and structural validity of measures that have been used to assess quality of life in people with DMD

	Content validity				Structural Validity
PROM	Relevance	Comprehensiveness	Comprehensibility	Quality of evidence	Rating of results	Quality of evidence
BDI	±	–	±	Very low	?	?
CALI	+	–	±	Low	?	?
DCGM-37	±	+	+	Low	?	?
EQ-5D-3L	+	–	+	Very low	?	?
FSS	±	–	±	Very low	?	?
GAD-7	+	–	+	Very low	?	?
HADS	–	–	–	Very low	?	?
HUI-2 / HUI-3 (15Q)	–	–	–	Very low	?	?
INQoL	±	±	+	Very low	?	?
KIDSCREEN-52	+	+	+	Low	?	?
KIDSCREEN-27	+	+	+	Low	?	?
KIDSCREEN-10	+	+	+	Low	?	?
LSIA	+	+	+	Moderate	?	?
MDCHILD	±	+	+	Low	?	?
PedsQL 3.0 DMD	±	?	±	Very low	?	?
PedsQL 3.0 MFS	±	–	±	Very low	?	?
PedsQL 3.0 NMM	±	?	±	Moderate	–	High
PedsQL 4.0 GCS	±	+	±	Low	?	Very low
PedsQL 4.0 SF-15	±	+	±	Low	?	?
PHQ-9	+	–	±	Very low	?	?
PODCI	±	+	±	Very low	?	?
PSQI	±	–	±	Very low	?	?
SDQ	–	–	+	Very low	?	?
SF-36 v1.0	±	+	±	Very low	?	?
SWLS	–	–	±	Very low	?	?
WHOQOL-BREF	+	+	±	Very low	?	?

+ = satisfactory results; − = unsatisfactory results; ± = inconsistent results;? = indeterminate. PROM = patient reported outcome measure