TABLE 1.
Baseline Characteristics of Study Population
| Variable | Overall | Underweight | Normal Weight | Overweight | Obese | P |
|---|---|---|---|---|---|---|
| Patients, No. (%) | 3719 (100) | 1059 (28.5) | 1649 (44.3) | 423 (11.4) | 588 (15.8) | — |
| Male sex, No. (%) | 2070 (55.7) | 609 (57.5) | 883 (53.6) | 221 (52.3) | 357 (60.7) | .006 |
| Race or ethnicity, No. (%) | ||||||
| White | 2222 (59.8) | 642 (60.6) | 994 (60.3) | 240 (56.7) | 346 (58.8) | .5 |
| Black or African American | 587 (15.8) | 138 (13.0) | 257 (15.6) | 81 (19.2) | 111 (18.9) | .003 |
| American Indian | 40 (1.1) | 7 (0.7) | 17 (1.0) | 5 (1.2) | 11 (1.9) | .2 |
| Asian | 413 (11.1) | 143 (13.5) | 173 (10.5) | 47 (11.1) | 50 (8.5) | .01 |
| Hispanic | 20 (0.5) | 8 (0.8) | 7 (0.4) | 4 (1.0) | 1 (0.2) | .3 |
| Other or unknown | 451 (12.1) | 127 (12.0) | 206 (12.5) | 49 (11.6) | 69 (11.7) | .9 |
| Region, No. (%) | .01 | |||||
| Australia | 200 (5.4) | 53 (5.0) | 96 (5.8) | 17 (4.0) | 34 (5.8) | |
| East Asia | 308 (8.3) | 109 (10.3) | 116 (7.0) | 39 (9.2) | 44 (7.5) | |
| Europe | 285 (7.7) | 98 (9.3) | 127 (7.7) | 22 (5.2) | 38 (6.5) | |
| North America | 2926 (78.7) | 799 (75.5) | 1310 (79.4) | 345 (81.6) | 472 (80.3) | |
| Age, mo, median (IQR) | 64.4 (19–149.6) | 53.4 (17.4–141.2) | 64.1 (17.8–149.9) | 83.5 (21.5–166.3) | 70.8 (24.5–146.4) | .001 |
| Wt at ICU admission, kg, median (IQR) | 18.8 (10.7–40.0) | 13.3 (8–26.6) | 18.7 (10.4–40.9) | 25.8 (13.2–61.8) | 32.8 (16.8–70.3) | <.0001 |
| Admission diagnosis, No. (%) | ||||||
| Sepsis | 542 (14.6) | 188 (17.8) | 230 (14.0) | 58 (13.7) | 66 (11.2) | .002 |
| Shock | 791 (21.3) | 226 (21.3) | 347 (21.0) | 104 (24.6) | 114 (19.4) | .3 |
| Cardiovascular | 153 (4.1) | 45 (4.3) | 66 (4.0) | 21 (5.0) | 21 (3.6) | .7 |
| Respiratory failure | 1460 (39.3) | 472 (44.6) | 637 (38.6) | 147 (34.8) | 204 (34.7) | <.0001 |
| Surgical or trauma | 1209 (32.5) | 346 (32.7) | 520 (31.5) | 126 (29.8) | 217 (36.9) | .06 |
| Central nervous system | 663 (17.8) | 167 (15.8) | 303 (18.4) | 84 (19.9) | 109 (18.5) | .2 |
| Pain management or sedation | 131 (3.5) | 42 (4.0) | 58 (3.5) | 13 (3.1) | 18 (3.1) | .7 |
| No. comorbidities, median (IQR) | 1 (1–2) | 2 (1–3) | 1 (1–2) | 1 (1–2) | 1 (1–2) | <.0001 |
| At least 3 comorbidities, No. (%) | 795 (21.4) | 360 (34.0) | 298 (18.1) | 56 (13.2) | 81 (13.8) | <.0001 |
| Comorbidity, No. (%) | ||||||
| Cardiovascular | 480 (12.9) | 194 (18.3) | 187 (11.3) | 43 (10.2) | 56 (9.5) | <.0001 |
| Pulmonary | 1440 (38.7) | 545 (51.5) | 569 (34.5) | 127 (30.0) | 199 (33.8) | <.0001 |
| Neurologic | 1338 (36.0) | 462 (43.6) | 511 (31.0) | 148 (35.0) | 217 (36.9) | <.0001 |
| Gastrointestinal | 730 (19.6) | 331 (31.3) | 283 (17.2) | 51 (12.1) | 65 (11.1) | <.0001 |
| Renal or urologic | 237 (6.4) | 94 (8.9) | 92 (5.6) | 27 (6.4) | 24 (4.1) | .0004 |
| Hematologic | 235 (6.3) | 87 (8.2) | 103 (6.3) | 17 (4.0) | 28 (4.8) | .006 |
| Immunologic | 86 (2.3) | 36 (3.4) | 37 (2.2) | 7 (1.7) | 6 (1.0) | .01 |
| Infectious disease | 300 (8.1) | 101 (9.5) | 127 (7.7) | 32 (7.6) | 40 (6.8) | .2 |
| Rheumatologic | 36 (1.0) | 12 (1.1) | 20 (1.2) | 4 (1.0) | 0 (0) | .02a |
| Neuromuscular | 460 (12.4) | 206 (19.5) | 177 (10.7) | 35 (8.3) | 42 (7.1) | <.0001 |
| Metabolic | 450 (12.1) | 167 (15.8) | 180 (10.9) | 45 (10.6) | 58 (9.9) | .0002 |
—, not applicable.
a
P value from Fisher’s exact test.