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. 2020 Aug 1;2(3):zcaa013. doi: 10.1093/narcan/zcaa013

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© The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — XRCC1 and MRE11 gene expression is correlated with poor survival in HR-deficient breast cancer patients. (A) Distribution of signature 3 score across all breast cancers in TCGA. (B) Kaplan–Meier survival curve and hazard ratio for all TCGA breast cancer patients with high (top 20%) and low (bottom 20%) gene expression levels (panel D) of XRCC1. (C) Kaplan–Meier survival curve and hazard ratio for all TCGA breast cancer patients with high (top 20%) and low (bottom 20%) gene expression levels (panel G) of MRE11. Kaplan–Meier survival curves and hazard ratios for Sig3-negative (HR-positive, E) and Sig3-positive (HR-negative, F) breast cancer patients with high and low expression of XRCC1. Kaplan–Meier survival curves and hazard ratios for Sig3-negative (HR-positive, H) and Sig3-positive (HR-negative, I) breast cancer patients with high and low expression of MRE11.