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. Author manuscript; available in PMC: 2020 Oct 21.
Published in final edited form as: Chem Res Toxicol. 2019 Sep 10;32(10):1965–1976. doi: 10.1021/acs.chemrestox.9b00112

Table 1.

Kinetic Constants of Recombined Human P450s for Elemicin Metabolism

enzyme Vmax (nmol min−1 nmol P450−1)a Km (μM)a in vitro catalytic efficiency (μL min−1 nmol P450−1)b
CYP1A1 1.804 ± 0.045 12.880 ± 1.265 140.062
CYP1A2 0.402 ± 0.021 15.850 ± 3.067 25.363
CYP2A6 0.524 ± 0.110 1007.000 ± 293.000 0.520
CYP2C19 0.475 ± 0.012 43.430 ± 3.613 10.933
CYP3A4 0.262 ± 0.026 196.700 ± 46.190 1.332
a

Mean values of three independent measurements ± SD.

b

In vitro catalytic efficiency = Vmax/Km × 1000 μL.