TABLE 3.
Lipid composition of LDL and HDL
| Adenovirus | TC | FC | CE | TG | PL | S/C |
| μg / mg protein | ||||||
| LDL | ||||||
| Null | 994.5 ± 41.8 | 298.8 ± 23.6 | 1,175.8 ± 44.5 | 539.3 ± 51.5 | 920.7 ± 14.7 | 1.30 ± 0.04 |
| haCETP | 1,058.9 ± 28.4 | 277.0 ± 13.3 | 1,321.5 ± 43.5a | 382.5 ± 21.8b | 973.5 ± 31.2 | 1.33 ± 0.04 |
| huCETP | 1,054.6 ± 49.5 | 227.5 ± 16.0a,c | 1,397.9 ± 75.5a | 633.4 ± 81.9d | 1,108.2 ± 36.1b,c | 1.15 ± 0.02b,d |
| HDL | ||||||
| Null | 328.6 ± 5.3 | 38.8 ± 2.7 | 489.7 ± 10.7 | 3.1 ± 0.3 | 583.1 ± 21.2 | 3.17 ± 0.07 |
| haCETP | 326.5 ± 5.7 | 28.7 ± 2.2b | 503.2 ± 11.4 | 2.9 ± 0.4 | 578.0 ± 10.6 | 3.09 ± 0.05 |
| huCETP | 193.5 ± 7.3b,d | 15.4 ± 2.0 b,d | 301.1 ± 13.5b,d | 20.9 ± 3.4b,d | 520.7 ± 23.1 | 4.69 ± 0.15b,d |
The cholesterol (TC), FC, CE, TG, and phospholipid (PL) content of LDL and HDL were quantified. The ratio of components residing in the LDL surface (S) and core (C) was calculated as: (Protein + PL + FC)/(CE + TG). For HDL, this calculation assumes 40% of FC resides in the core (59). Mean ± SEM, n = 8 (null), 11 (haCETP), 7 (huCETP).
a
P < 0.05 versus Ad-null.
b
P < 0.01 versus Ad-null.
c
P < 0.05 versus Ad-haCETP.
d
P < 0.01 versus Ad-haCETP.